What are the causes of disease? Heart diseases have many causes. Atherosclerosis, or choke arteries is partially or major general responsible for many diseases affecting the heart, such as: heart attacks, called myocardial heart attacks and heart-congestion-pectoral angina or nepectorala, diseases in which pain in the chest when when the heart does not receive enough oxygen-irregular heart beat or arrhythmias such as ventricular tachycardia, other causes of heart disease include: valvulelor infe